Round 1 : Carthage vs Rome
In a bold and brilliant move, Carthage moved through to secure a foothold on the Italian peninsula through the remaining Greek colonies before Rome was able to uproot them. Threatened by this act, Rome declared war on Carthage as soon as they established control.
Several lengthy clashes later, Rome gives in to Carthaginian demands, and Carthage turns back to putting down several sizable rebellions at home.